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ALAT-2 laser aggregation analyzer
The BIOLA aggregation analyzers are designed to study platelet aggregation, as well as to determine the concentration of cells in suspension and to assess their shape.
Specifications
Measurement of independent cells
Pre-incubation cells per measuring cell
Sample volume
Operating range of concentrations
Probe thermostatics
Mixing speed
Aggregation, Born method
Aggregation, ODFA method
Platelet concentration assessment
Von Willebrand factor measurement
Power supply
Power consumption
Interface for connecting to a PC
Software
Weight
LA220
Measurement of independent cells
Pre-incubation cells per measuring cell
Sample volume
Operating range of concentrations
Probe thermostatics
Mixing speed
Aggregation, Born method
Aggregation, ODFA method
Platelet concentration assessment
Von Willebrand factor measurement
Power supply
Power consumption
Interface for connecting to a PC
Software
Weight
2
2
0.3 ml
50–500 thousands/µl
25–42 ±1°C
100–1200 rpm
✓
✓
✕
✕
included
220 V
25 VA
USB
up to 3.1 kg
LA230
Measurement of independent cells
Pre-incubation cells per measuring cell
Sample volume
Operating range of concentrations
Probe thermostatics
Mixing speed
Aggregation, Born method
Aggregation, ODFA method
Platelet concentration assessment
Von Willebrand factor measurement
Power supply
Power consumption
Interface for connecting to a PC
Software
Weight
2
2
0.3 ml
50–500 thousands/µl
25–42 ±1°C
100–1200 rpm
✓
✓
✓
✕
Included
220 V
25 VA
USB
up to 3.1 kg
LA230-2
Measurement of independent cells
Pre-incubation cells per measuring cell
Sample volume
Operating range of concentrations
Probe thermostatics
Mixing speed
Aggregation, Born method
Aggregation, ODFA method
Platelet concentration assessment
Von Willebrand factor measurement
Power supply
Power consumption
Interface for connecting to a PC
Software
Weight
2
2
0.3 ml
50–500 thousands/µl
25–42 ±1°C
100–1200 rpm
✓
✓
✓
✓
Included
220 V
25 VA
USB
up to 3.1 kg
LA420
Measurement of independent cells
Pre-incubation cells per measuring cell
Sample volume
Operating range of concentrations
Probe thermostatics
Mixing speed
Aggregation, Born method
Aggregation, ODFA method
Platelet concentration assessment
Von Willebrand factor measurement
Power supply
Power consumption
Interface for connecting to a PC
Software
Weight
4
2
0.3 ml
50–500 thousands/µl
25–42 ±1°C
100–1200 rpm
✓
✓
✕
✕
Included
220 V
25 VA
USB
up to 3.1 kg
LA430
Measurement of independent cells
Pre-incubation cells per measuring cell
Sample volume
Operating range of concentrations
Probe thermostatics
Mixing speed
Aggregation, Born method
Aggregation, ODFA method
Platelet concentration assessment
Von Willebrand factor measurement
Power supply
Power consumption
Interface for connecting to a PC
Software
Weight
4
2
0.3 ml
50–500 thousands/µl
25–42 ±1°C
100–1200 rpm
✓
✓
✓
✕
Included
220 V
25 VA
USB
up to 3.1 kg
LA430-2
Measurement of independent cells
Pre-incubation cells per measuring cell
Sample volume
Operating range of concentrations
Probe thermostatics
Mixing speed
Aggregation, Born method
Aggregation, ODFA method
Platelet concentration assessment
Von Willebrand factor measurement
Power supply
Power consumption
Interface for connecting to a PC
Software
Weight
4
2
0.3 ml
50–500 thousands/µl
25–42 ±1°C
100–1200 rpm
✓
✓
✓
✓
Included
220 V
25 VA
USB
up to 3.1 kg
ALAT-2 offers two methods for platelet aggregation research: the turbidimetric method (the Born method) and the Optical Density Fluctuation Analysis (ODFA) method.
The turbidimetric method proposed by Born and O’Brien is the most common method that is used in researching aggregation. By registering the changes in the optical density of platelet-rich plasma it allows investigating not only the aggregation, but also the changes in the shape of cells. The latter is particular important, because the changes in platelet shape can mask the initial stage of aggregation. It has been established that the formation of microaggregates (consisting of less than 100 platelets) may not affect the optical density in a suspension.
The ODFA method proposed by Z.A. and co-authors in 1989 is associated with a change in the average radius of the aggregates and is based on the analysis of light transmission fluctuations caused by a random change in the number of particles in the optical channel. The relative dispersion of such fluctuations is proportional to the average size of the aggregates and is used to study the aggregation kinetics. Remarkably high sensitivity of the ODFA method makes it employable in studying spontaneous aggregation, aggregation under the action of low concentrations of inducers, as well as aggregation of subcellular particles and macromolecules. Further studies by Biola LTD specialists proved possible to evaluate the concentration of particles in stirred suspension.
Field of application
- Diagnosis of platelet condition in hemostasis;
- Diagnosis of congenital and acquired hemostasis disorders;
- Evaluation of the effectiveness of therapy and the degree of impact on the aggregation;
- creening new drugs;
- Evaluation of the viability of platelet mass during blood transfusion;
- Toxicology;
- Evaluation of the form and number of platelets;
- Quantitative determination of von Willebrand factor;
- Aggregation is recorded both by the traditional turbidimetric method and by the method based on real-time measurement of aggregate mean size.
Related products
Distinctive features
- Each measuring cell operates independently: you can run several measurements simultaneously.
- Born and average radius measurements are also performed simultaneously: two graphs are displayed on the computer screen in real time.
- The analyzer does not require special care or maintenance.
- All required materials are supplied with the product: the amount of reagents and consumables in the kit will be sufficient for half a year of work of a small laboratory.
- Operating this product does not require a powerful computer: any PC with an installed Windows operating systen and a free USB port is enough.
- Training on the basis of the laboratory of the Institute of Experimental Cardiology of the RKNPK Ministry of Health of the Russian Federation in Moscow: even if you are not the owner of the device, come to us to learn aggregation.
- The manufacturer provides support for the equipment even after the expiration of the warranty period: if we can fix it for free, we will repair it for free.
Documents
Training
Aggregometers made by “BIOLA” are the most reliable and easy to use. We present a free course on how to work with the device, regardless of whether the device was purchased from us or a third-party dealer. We offer a three-day program in which the operator will obtain the necessary knowledge and practice skills. The program includes theoretical and practical training, as well as the study of software and hardware features of the ALAT2 “Biola” device. Professionals in the field of aggregometry will suggest the correct methodology for conducting research, as well as a wealth of useful information on the interpretation of the results.
Training is conducted at the Institute of Experimental Cardiology (IAC), Russian Cardiology Research and Production Complex (FBGU Cardiology MZ RF)
Aggregometry school
03-04 April 2018 Attendance at the event is free for everyone. Please confirm your participation by phone in a week. Contact person — Evgeny Popov Phone: 8 (495) 414-67-47 / 48Mobile: +7 916 149-51-99
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